Pesquisa | Secretaria de Estado da Saúde

1.

Genome-wide characterization of circulating metabolic biomarkers.

Karjalainen, Minna K; Karthikeyan, Savita; Oliver-Williams, Clare; Sliz, Eeva; Allara, Elias; Fung, Wing Tung; Surendran, Praveen; Zhang, Weihua; Jousilahti, Pekka; Kristiansson, Kati; Salomaa, Veikko; Goodwin, Matt; Hughes, David A; Boehnke, Michael; Fernandes Silva, Lilian; Yin, Xianyong; Mahajan, Anubha; Neville, Matt J; van Zuydam, Natalie R; de Mutsert, Renée; Li-Gao, Ruifang; Mook-Kanamori, Dennis O; Demirkan, Ayse; Liu, Jun; Noordam, Raymond; Trompet, Stella; Chen, Zhengming; Kartsonaki, Christiana; Li, Liming; Lin, Kuang; Hagenbeek, Fiona A; Hottenga, Jouke Jan; Pool, René; Ikram, M Arfan; van Meurs, Joyce; Haller, Toomas; Milaneschi, Yuri; Kähönen, Mika; Mishra, Pashupati P; Joshi, Peter K; Macdonald-Dunlop, Erin; Mangino, Massimo; Zierer, Jonas; Acar, Ilhan E; Hoyng, Carel B; Lechanteur, Yara T E; Franke, Lude; Kurilshikov, Alexander; Zhernakova, Alexandra; Beekman, Marian.

Nature ; 628(8006): 130-138, 2024 Apr.

Artigo Inglês | MEDLINE | ID: mdl-38448586

2.

Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci.

Li, Yi; Xiong, Ziyi; Zhang, Manfei; Hysi, Pirro G; Qian, Yu; Adhikari, Kaustubh; Weng, Jun; Wu, Sijie; Du, Siyuan; Gonzalez-Jose, Rolando; Schuler-Faccini, Lavinia; Bortolini, Maria-Catira; Acuna-Alonzo, Victor; Canizales-Quinteros, Samuel; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Rothhammer, Francisco; Wang, Jiucun; Tan, Jingze; Yuan, Ziyu; Jin, Li; Uitterlinden, André G; Ghanbari, Mohsen; Ikram, M Arfan; Nijsten, Tamar; Zhu, Xiangyu; Lei, Zhen; Jia, Peilin; Ruiz-Linares, Andres; Spector, Timothy D; Wang, Sijia; Kayser, Manfred; Liu, Fan.

PLoS Genet ; 19(7): e1010786, 2023 07.

Artigo Inglês | MEDLINE | ID: mdl-37459304

3.

Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.

Dehghan, Abbas; Pinto, Rui Climaco; Karaman, Ibrahim; Huang, Jian; Durainayagam, Brenan R; Ghanbari, Mohsen; Nazeer, Areesha; Zhong, Qi; Liggi, Sonia; Whiley, Luke; Mustafa, Rima; Kivipelto, Miia; Solomon, Alina; Ngandu, Tiia; Kanekiyo, Takahisa; Aikawa, Tomonori; Radulescu, Carola I; Barnes, Samuel J; Graça, Gonçalo; Chekmeneva, Elena; Camuzeaux, Stephane; Lewis, Matthew R; Kaluarachchi, Manuja R; Ikram, M Arfan; Holmes, Elaine; Tzoulaki, Ioanna; Matthews, Paul M; Griffin, Julian L; Elliott, Paul.

Proc Natl Acad Sci U S A ; 119(43): e2206083119, 2022 10 25.

Artigo Inglês | MEDLINE | ID: mdl-36269859

4.

Genetic architecture of orbital telorism.

Knol, Maria J; Pawlak, Mikolaj A; Lamballais, Sander; Terzikhan, Natalie; Hofer, Edith; Xiong, Ziyi; Klaver, Caroline C W; Pirpamer, Lukas; Vernooij, Meike W; Ikram, M Arfan; Schmidt, Reinhold; Kayser, Manfred; Evans, Tavia E; Adams, Hieab H H.

Hum Mol Genet ; 31(9): 1531-1543, 2022 05 04.

Artigo Inglês | MEDLINE | ID: mdl-34791242

5.

Fat metabolism is associated with telomere length in six population-based studies.

van der Spek, Ashley; Karamujic-Comic, Hata; Pool, René; Bot, Mariska; Beekman, Marian; Garmaeva, Sanzhima; Arp, Pascal P; Henkelman, Sandra; Liu, Jun; Alves, Alexessander Couto; Willemsen, Gonneke; van Grootheest, Gerard; Aubert, Geraldine; Ikram, M Arfan; Jarvelin, Marjo-Riitta; Lansdorp, Peter; Uitterlinden, André G; Zhernakova, Alexandra; Slagboom, P Eline; Penninx, Brenda W J H; Boomsma, Dorret I; Amin, Najaf; van Duijn, Cornelia M.

Hum Mol Genet ; 31(7): 1159-1170, 2022 03 31.

Artigo Inglês | MEDLINE | ID: mdl-34875050

6.

Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.

Portilla-Fernandez, Eliana; Klarin, Derek; Hwang, Shih-Jen; Biggs, Mary L; Bis, Joshua C; Weiss, Stefan; Rospleszcz, Susanne; Natarajan, Pradeep; Hoffmann, Udo; Rogers, Ian S; Truong, Quynh A; Völker, Uwe; Dörr, Marcus; Bülow, Robin; Criqui, Michael H; Allison, Matthew; Ganesh, Santhi K; Yao, Jie; Waldenberger, Melanie; Bamberg, Fabian; Rice, Kenneth M; Essers, Jeroen; Kapteijn, Daniek M C; van der Laan, Sander W; de Knegt, Rob J; Ghanbari, Mohsen; Felix, Janine F; Ikram, M Arfan; Kavousi, Maryam; Uitterlinden, Andre G; Roks, Anton J M; Danser, A H Jan; Tsao, Philip S; Damrauer, Scott M; Guo, Xiuqing; Rotter, Jerome I; Psaty, Bruce M; Kathiresan, Sekar; Völzke, Henry; Peters, Annette; Johnson, Craig; Strauch, Konstantin; Meitinger, Thomas; O'Donnell, Christopher J; Dehghan, Abbas.

Hum Mol Genet ; 31(20): 3566-3579, 2022 10 10.

Artigo Inglês | MEDLINE | ID: mdl-35234888

7.

Plasma circulating microRNAs associated with blood-based immune markers: a population-based study.

Leonard, Samantha; Karabegovic, Irma; Ikram, M Arfan; Ahmad, Shahzad; Ghanbari, Mohsen.

Clin Exp Immunol ; 215(3): 251-260, 2024 Feb 19.

Artigo Inglês | MEDLINE | ID: mdl-37950349

8.

Fatty liver disease is not associated with increased mortality in the elderly: A prospective cohort study.

van Kleef, Laurens A; Sonneveld, Milan J; Kavousi, Maryam; Ikram, M Arfan; de Man, Robert A; de Knegt, Robert J.

Hepatology ; 77(2): 585-593, 2023 02 01.

Artigo Inglês | MEDLINE | ID: mdl-35753042

9.

Plasma proteomic signature of fatty liver disease: The Rotterdam Study.

Abozaid, Yasir J; Ayada, Ibrahim; van Kleef, Laurens A; Vallerga, Costanza L; Pan, Qiuwei; Brouwer, Willem P; Ikram, M Arfan; Van Meurs, Joyce; de Knegt, Robert J; Ghanbari, Mohsen.

Hepatology ; 78(1): 284-294, 2023 07 01.

Artigo Inglês | MEDLINE | ID: mdl-36738080

10.

Towards a Clearer Causal Question Underlying the Association Between Cancer and Dementia.

Rojas-Saunero, L Paloma; van der Willik, Kimberly D; Schagen, Sanne B; Ikram, M Arfan; Swanson, Sonja A.

Epidemiology ; 35(3): 281-288, 2024 May 01.

Artigo Inglês | MEDLINE | ID: mdl-38442423

11.

Smoking-related dysregulation of plasma circulating microRNAs: the Rotterdam study.

Karabegovic, Irma; Maas, Silvana C E; Shuai, Yu; Ikram, M Arfan; Stricker, Bruno; Aerts, Joachim; Brusselle, Guy; Lahousse, Lies; Voortman, Trudy; Ghanbari, Mohsen.

Hum Genomics ; 17(1): 61, 2023 07 10.

Artigo Inglês | MEDLINE | ID: mdl-37430296

12.

Circulating metabolites modulated by diet are associated with depression.

van der Spek, Ashley; Stewart, Isobel D; Kühnel, Brigitte; Pietzner, Maik; Alshehri, Tahani; Gauß, Friederike; Hysi, Pirro G; MahmoudianDehkordi, Siamak; Heinken, Almut; Luik, Annemarie I; Ladwig, Karl-Heinz; Kastenmüller, Gabi; Menni, Cristina; Hertel, Johannes; Ikram, M Arfan; de Mutsert, Renée; Suhre, Karsten; Gieger, Christian; Strauch, Konstantin; Völzke, Henry; Meitinger, Thomas; Mangino, Massimo; Flaquer, Antonia; Waldenberger, Melanie; Peters, Annette; Thiele, Ines; Kaddurah-Daouk, Rima; Dunlop, Boadie W; Rosendaal, Frits R; Wareham, Nicholas J; Spector, Tim D; Kunze, Sonja; Grabe, Hans Jörgen; Mook-Kanamori, Dennis O; Langenberg, Claudia; van Duijn, Cornelia M; Amin, Najaf.

Mol Psychiatry ; 28(9): 3874-3887, 2023 Sep.

Artigo Inglês | MEDLINE | ID: mdl-37495887

13.

Progression of arterial calcifications: what, where, and in whom?

van der Toorn, Janine E; Vernooij, Meike W; Ikram, M Arfan; Kavousi, Maryam; Bos, Daniel.

Eur Radiol ; 2024 Jan 15.

Artigo Inglês | MEDLINE | ID: mdl-38224376

14.

Nonalcoholic fatty liver disease, liver fibrosis, and structural brain imaging: The Cross-Cohort Collaboration.

Weinstein, Galit; O'Donnell, Adrienne; Frenzel, Stefan; Xiao, Tian; Yaqub, Amber; Yilmaz, Pinar; de Knegt, Robert J; Maestre, Gladys E; Melo van Lent, Debora; Long, Michelle; Gireud-Goss, Monica; Ittermann, Till; Frost, Fabian; Bülow, Robin; Vasan, Ramachandran S; Grabe, Hans J; Ikram, M Arfan; Beiser, Alexa S; Seshadri, Sudha.

Eur J Neurol ; 31(1): e16048, 2024 01.

Artigo Inglês | MEDLINE | ID: mdl-37641505

15.

Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study.

van Arendonk, Joyce; Neitzel, Julia; Steketee, Rebecca M E; van Assema, Daniëlle M E; Vrooman, Henri A; Segbers, Marcel; Ikram, M Arfan; Vernooij, Meike W.

Brain ; 146(1): 337-348, 2023 01 05.

Artigo Inglês | MEDLINE | ID: mdl-36374264

16.

Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI.

Yang, Yunju; Knol, Maria J; Wang, Ruiqi; Mishra, Aniket; Liu, Dan; Luciano, Michelle; Teumer, Alexander; Armstrong, Nicola; Bis, Joshua C; Jhun, Min A; Li, Shuo; Adams, Hieab H H; Aziz, Nasir Ahmad; Bastin, Mark E; Bourgey, Mathieu; Brody, Jennifer A; Frenzel, Stefan; Gottesman, Rebecca F; Hosten, Norbert; Hou, Lifang; Kardia, Sharon L R; Lohner, Valerie; Marquis, Pascale; Maniega, Susana Muñoz; Satizabal, Claudia L; Sorond, Farzaneh A; Valdés Hernández, Maria C; van Duijn, Cornelia M; Vernooij, Meike W; Wittfeld, Katharina; Yang, Qiong; Zhao, Wei; Boerwinkle, Eric; Levy, Daniel; Deary, Ian J; Jiang, Jiyang; Mather, Karen A; Mosley, Thomas H; Psaty, Bruce M; Sachdev, Perminder S; Smith, Jennifer A; Sotoodehnia, Nona; DeCarli, Charles S; Breteler, Monique M B; Ikram, M Arfan; Grabe, Hans J; Wardlaw, Joanna; Longstreth, W T; Launer, Lenore J; Seshadri, Sudha.

Brain ; 146(2): 492-506, 2023 02 13.

Artigo Inglês | MEDLINE | ID: mdl-35943854

17.

The Rotterdam Study. Design update and major findings between 2020 and 2024.

Ikram, M Arfan; Kieboom, Brenda C T; Brouwer, Willem Pieter; Brusselle, Guy; Chaker, Layal; Ghanbari, Mohsen; Goedegebure, André; Ikram, M Kamran; Kavousi, Maryam; de Knegt, Rob J; Luik, Annemarie I; van Meurs, Joyce; Pardo, Luba M; Rivadeneira, Fernando; van Rooij, Frank J A; Vernooij, Meike W; Voortman, Trudy; Terzikhan, Natalie.

Eur J Epidemiol ; 39(2): 183-206, 2024 Feb.

Artigo Inglês | MEDLINE | ID: mdl-38324224

18.

Plasma neurofilament light chain in association to late-life depression in the general population.

Schuurmans, Isabel K; Ghanbari, Mohsen; Cecil, Charlotte A M; Ikram, M Arfan; Luik, Annemarie I.

Psychiatry Clin Neurosci ; 78(2): 97-103, 2024 Feb.

Artigo Inglês | MEDLINE | ID: mdl-37843431

19.

Antidepressant use in relation to dementia risk, cognitive decline, and brain atrophy.

Vom Hofe, Ilse; Stricker, Bruno H; Vernooij, Meike W; Ikram, M Kamran; Ikram, M Arfan; Wolters, Frank J.

Alzheimers Dement ; 2024 Apr 01.

Artigo Inglês | MEDLINE | ID: mdl-38561253

20.

Intracranial arteriosclerosis and the risk of dementia: A population-based cohort study.

van den Beukel, Tim C; Wolters, Frank J; Siebert, Uwe; Spiering, Wilko; Ikram, M Arfan; Vernooij, Meike W; de Jong, Pim A; Bos, Daniel.

Alzheimers Dement ; 20(2): 869-879, 2024 Feb.

Artigo Inglês | MEDLINE | ID: mdl-37814499

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